Is Stem Cell Therapy (BMC) Safe? Published Research

Every published BMC study must assess both safety and efficacy of the therapy. In the 30+ years of BMC use in orthopedics, thousands of studies have been published, each affirming the safety of BMC therapy. Below are just a few of those studies showing the extensive history of safe BMC intervention in orthopedic applications.

Treatment of Hemophilic Ankle Arthropathy with One-Step Arthroscopic Bone Marrow–Derived Cells Transplantation

Buda R, Cavallo M, Castagnini F, et al.

Cartilage. 2015;6(3):150-155. doi:10.1177/1947603515574286

Anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow nucleated cells: a case series

Centeno CJ, Pitts J, Al-Sayegh H, Freeman MD

J Pain Res (2015) 8:437–447. doi:10.2147/JPR.S86244

Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft.

Centeno C, Pitts J, Al-Sayegh H, Freeman M

Bio Med Res Int (2014):370621–370629.doi:10.1155/2014/370621

Treatment of osteonecrosis with autologous bone marrow grafting

Hernigou P, Beaujean F

Clin Orthop Relat Res (2002)  405(405):14–23. doi:10.1097/00003086-200212000-00003

Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells

Hernigou P, Poignard A, Beaujean F, Rouard H

J Bone Joint Surg (2005) (Am Vol) 87(7):1430. doi:10.2106/JBJS.D.02215

Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes

Hernigou P, Guissou I, Homma Y, et al.

Int Orthop. 2015;39(8):1639-1643. doi:10.1007/s00264-015-2738-2

Cancer risk is not increased inpatients treated for orthopaedic diseases with autologous bone marrow cell concentrate

Hernigou P, Homma Y, Flouzat-Lachaniette C-H, Poignard A,Chevallier N, Rouard H

J Bone Joint Surg (2013) (Am Vol) 95(24):2215. doi:10.2106/JBJS.M.

Cell therapy of hip osteonecrosis with autologous bone marrow grafting

Hernigou P, Poignard A, Zilber S, Rouard H

Ind J Orthop (2009)  43(1):40–45. doi:10.4103/0019-5413.45322

Local transplantation of bone marrow concentrated granulocytes precursors can cure without antibiotics infected nonunion of polytraumatic patients in absence of bone defect.

Hernigou P, Trousselier M, Roubineau F, et al.

Int Orthop. 2016;40(11):2331-2338. doi:10.1007/s00264-016-3147-x

Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months

Pettine KA, Murphy MB, Suzuki RK, Sand TT.

Stem Cells. 2015;33(1):146-156. doi:10.1002/stem.1845